Laying The Foundation Harvard Case Solution & Analysis

1. How do neurotransmitters “talk back” to presynaptic neurons?
Neuron refers to the cell of the nervous system which communicates through anelectrochemical process.There are around 100 billion neurons in the brain.Neurotransmission is also known as synaptic transmission in which the chemicals transmit signals from one neuron (presynaptic neuron) to another. However, these neurons do not touch one anotherbut have a gap between them which is called synapse. There arefive processes involved for the neurotransmitters to communicate with the presynaptic neurons.
1. The first step is the neurotransmitters synthesis in which the small-molecule transmitters (amines or amino acids) are synthesized.
2. After the neurotransmitters are synthesized they are further stored into vesicles for future use.
3. The vesicles of neurotransmitters are released once theyreceive order from Ca 2+ ions and are expelled into the synaptic cleft.
Laying The Foundation Harvard Case Solution & Analysis

4. Once the neurotransmitters are released they are sent to postsynaptic neurons.
5. After the neurotransmittersreach to the postsynaptic neurons, the postsynaptic arecleared.
2. How do you understand the inter-relationship between epigenetic instability as it is related to what the individual experiences? Explain how this a good thing or a bad thing.
Epigenetic instability refers to the changes of genes which are not generally involved with the changes in DNA but arehighly influenced by several factors such as age, avariety of illness, environment, and lifestyle. Epigenetic instability is concerned with the phenotype (physical activities which are combined with both organism genes and environmental influence) rather than complete genetic. As a person grows up, he would experience epigenetic instability which is influenced by the environmental or may be due to illness. This would result in the changes inindividual experience by behaving differently with other people. If a person has lived in a good environment and does not suffer from any major illness, he would act well among others whereas if a person who had lived in a bad environment or suffers from any major illness then the person would behave differently or rudely among other people. Epigenetic instability is mainly concerned with the change of genes which influences on a person’s thinking and behavior.
3. How are agonist, antagonist and partial agonists different?
Agonist refers to the chemical which binds the receptor of the brain in order to create a reaction or a response.The receptor is a part of the nervewhich reads the chemical signals and further transmits the information to the brain through electric signals.
Whereas antagonist is the opposite of agonist as it blocks the response by binding the receptor. The agonist and antagonist are the major factors which influence the human body and pharmacology.
Partial agonist refers to the intrinsic activity which produces lower than the full agonist. It produces 100% response rate by expressing on the scale of percentage. It varies from antagonist on the basis of receptivity of responses from the receptor which does not measure on a percentage scale basis and is often measured by the test system..................

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